IL-15 and psoriasis: another genetic link to Th17?

J Invest Dermatol. 2007 Nov;127(11):2495-7. doi: 10.1038/sj.jid.5700855.

Abstract

Interleukin-15 (IL-15) is a pro-inflammatory cytokine expressed in several inflammatory disorders. Zhang et al. (2007, this issue) report a significant genetic association between IL-15 and psoriasis, which may involve increased stability of IL-15 mRNA. Among its several activities, IL-15 stimulates the expression of IL-17 by T-cells. Together with recent genetic and therapeutic evidence implicating IL-23, these findings suggest a genetic basis for Th17-mediated inflammation in psoriasis.

Publication types

  • Comment

MeSH terms

  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism
  • Interleukin-15 / genetics
  • Interleukin-15 / metabolism*
  • Interleukin-17 / genetics
  • Interleukin-17 / metabolism*
  • Interleukin-23 / genetics
  • Interleukin-23 / metabolism
  • Polymorphism, Single Nucleotide / genetics
  • Psoriasis / genetics
  • Psoriasis / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • T-Lymphocytes / metabolism*
  • T-Lymphocytes / pathology

Substances

  • Interleukin-15
  • Interleukin-17
  • Interleukin-23
  • RNA, Messenger