[Primary cerebellar T-cell lymphoma]

Pathologe. 2008 Jul;29(4):301-4. doi: 10.1007/s00292-007-0951-5.
[Article in German]


Primary central nervous system T-cell lymphomas are rare and have to be differentiated from reactive lesions. It is therefore essential to use all possible tools to establish the diagnosis, including immunohistochemistry, molecular genetic analysis, and/or cytogenetic methods. In this paper we present the case of a primary cerebellar T-cell lymphoma in a 50-year-old man; a clonal T-cell receptor gene rearrangement was documented. After two cycles of methotrexate therapy the patient developed Pneumocystis carinii-induced pneumonia, dying 10 weeks after his diagnosis. The autopsy did not reveal any residual tumour.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Cerebellar Neoplasms / drug therapy
  • Cerebellar Neoplasms / pathology*
  • Fatal Outcome
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Lymphoma, T-Cell / drug therapy
  • Lymphoma, T-Cell / pathology*
  • Male
  • Methotrexate / therapeutic use
  • Middle Aged
  • Molecular Biology
  • Pneumocystis Infections / pathology*
  • Receptors, Antigen, T-Cell / genetics*


  • Receptors, Antigen, T-Cell
  • Methotrexate