Cytokine production by mast cells and basophils

Curr Opin Immunol. 1991 Dec;3(6):865-72. doi: 10.1016/s0952-7915(05)80005-6.


Mast cells and/or basophils have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, angiogenesis, tissue remodeling, and immunologically non-specific inflammatory and fibrotic conditions. Recent findings suggest that an important mechanism by which mast cells influence such biological responses is through the production of a broad panel of multifunctional cytokines. In contrast, the extent to which basophils can produce cytokines is uncertain.

Publication types

  • Review

MeSH terms

  • Animals
  • Basophils / immunology
  • Basophils / metabolism*
  • Cytokines / biosynthesis*
  • Cytokines / immunology
  • Humans
  • Inflammation / immunology
  • Mast Cells / immunology
  • Mast Cells / metabolism*
  • Mice


  • Cytokines