Prehospital induction of therapeutic hypothermia during CPR: a pilot study

Resuscitation. 2008 Mar;76(3):360-3. doi: 10.1016/j.resuscitation.2007.08.015. Epub 2007 Oct 23.


Aim of the study: We studied induction of therapeutic hypothermia during prehospital resuscitation from cardiac arrest using an infusion of ice-cold Ringer's solution in five adult patients.

Material and methods: Paramedics infused +4 degrees C Ringer's solution into the antecubital vein of the patients with a maximum rate of 33 ml/min to a target temperature of 33.0 degrees C.

Results: The mean infused volume of cold fluid was 14.0 ml/kg, which resulted in a mean decrease of 2.5 degrees C in nasopharyngeal temperature. The decrease in temperature continued after the cessation of infusion in two patients, causing suboptimal temperatures below 32 degrees C.

Conclusion: We conclude that the infusion of small volumes of ice-cold Ringer's solution during resuscitation results in an effective decrease in nasopharyngeal temperature. Caution should be taken to avoid temperatures below the range of mild therapeutic hypothermia.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Body Temperature
  • Cardiopulmonary Resuscitation*
  • Emergency Medical Services*
  • Feasibility Studies
  • Female
  • Heart Arrest / therapy*
  • Humans
  • Hypothermia, Induced / methods*
  • Infusions, Intravenous
  • Isotonic Solutions / administration & dosage
  • Male
  • Middle Aged
  • Pilot Projects
  • Ringer's Solution


  • Isotonic Solutions
  • Ringer's Solution