Role of chelates in treatment of cancer

Indian J Cancer. Apr-Jun 2007;44(2):62-71. doi: 10.4103/0019-509x.35813.

Abstract

Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy. Various chelates based on ruthenium, copper, zinc organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. This review is an attempt to compile the use of chelates as cytotoxic drugs and in radioimmunotherapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Cell Growth Processes / drug effects
  • Cell Growth Processes / radiation effects
  • Chelating Agents / therapeutic use
  • Chelation Therapy / trends*
  • Cytotoxins / therapeutic use
  • Drug Therapy / trends*
  • Humans
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Radioimmunotherapy / trends*
  • Radioisotopes / therapeutic use
  • Rats
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Chelating Agents
  • Cytotoxins
  • Radioisotopes