Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men

Prostate Cancer Prostatic Dis. 2008;11(3):264-9. doi: 10.1038/sj.pcan.4501022. Epub 2007 Oct 16.


Prior studies report slightly lower prostate-specific antigen (PSA) levels among obese men. To understand this effect, we investigated the association between PSA and blood HbA1c, C-peptide, leptin and adiponectin levels in African-American (AA) (n=121) and Caucasian (CA) (n=121) men. Among AA men, PSA levels decreased with increasing C-peptide levels (PSA=0.99, 0.93, 0.75 and 0.53 ng ml(-1) across quartiles of C-peptide, respectively; P(trend)=0.005). Among CA men, PSA levels decreased with increasing HbA1c (PSA=0.84, 0.73, 0.77 and 0.45 ng ml(-1) across quartiles of HbA1c, respectively; P(trend)=0.005). This may suggest that metabolic disturbances related to metabolic syndrome or diabetes affect the ability to detect early-stage prostate cancer.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adiponectin / blood
  • Adult
  • African Americans*
  • Aged
  • Body Mass Index
  • C-Peptide / blood*
  • Cohort Studies
  • Diabetes Complications / blood
  • Early Diagnosis
  • European Continental Ancestry Group*
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Leptin / blood*
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / complications
  • Middle Aged
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / ethnology


  • ADIPOQ protein, human
  • Adiponectin
  • C-Peptide
  • Glycated Hemoglobin A
  • Leptin
  • hemoglobin A1c protein, human
  • Prostate-Specific Antigen