Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis

Opt Lett. 2007 Oct 15;32(20):3002-4. doi: 10.1364/ol.32.003002.


The feasibility of photoacoustic tomography (PAT) in imaging human peripheral joints in a noninvasive manner was demonstrated through studies of cadaver human fingers. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the finger at the levels of the joints were visualized successfully with satisfactory spatial resolution. The imaging depth of PAT in the near-infrared region enables the cross-sectional imaging of a human finger as a whole organ. As a novel technology with unique advantages, PAT holds promise for early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis / pathology*
  • Equipment Design
  • Equipment Failure Analysis
  • Feasibility Studies
  • Finger Joint / pathology*
  • Humans
  • Image Enhancement / instrumentation*
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / instrumentation*
  • Image Interpretation, Computer-Assisted / methods
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Optical / instrumentation*
  • Ultrasonography / instrumentation*