Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium

Life Sci. 2007 Oct 13;81(17-18):1332-8. doi: 10.1016/j.lfs.2007.08.040. Epub 2007 Sep 19.


Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. In a murine model of AMI, based on ligation of the left coronary artery, administration of emodin reduced myocardial infarct size (MIS) in a dose-dependent manner. Emodin significantly suppressed TNF-alpha expression and NF-kappaB activation in the local myocardial infarction area. Treatment with emodin inhibited myocardial cell apoptosis by inhibiting caspase-3 activation. Therefore, these studies demonstrate that emodin protects against myocardial cell injury via suppression of local inflammation and apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Apoptosis / drug effects*
  • Blotting, Western
  • Disease Models, Animal
  • Electrophoretic Mobility Shift Assay
  • Emodin / pharmacology*
  • Emodin / therapeutic use
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Myocardial Infarction* / immunology
  • Myocardial Infarction* / pathology
  • Myocardial Infarction* / prevention & control
  • Myocardium* / enzymology
  • Myocardium* / immunology
  • Myocardium* / pathology
  • NF-kappa B / metabolism
  • Peroxidase / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / immunology


  • Anti-Inflammatory Agents, Non-Steroidal
  • NF-kappa B
  • Tumor Necrosis Factor-alpha
  • Peroxidase
  • Emodin