Cyclebase.org--a Comprehensive Multi-Organism Online Database of Cell-Cycle Experiments

Nucleic Acids Res. 2008 Jan;36(Database issue):D854-9. doi: 10.1093/nar/gkm729. Epub 2007 Oct 16.

Abstract

The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Cell Cycle / genetics*
  • Databases, Genetic*
  • Gene Expression Profiling
  • Genes, cdc*
  • Humans
  • Internet
  • Oligonucleotide Array Sequence Analysis
  • Saccharomycetales / genetics
  • Schizosaccharomyces / genetics
  • User-Computer Interface