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. 2007 Dec;100(6):1351-5.
doi: 10.1111/j.1464-410X.2007.07054.x. Epub 2007 Oct 17.

Long-term Follow-Up of Living Kidney Donors: A Longitudinal Study

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Long-term Follow-Up of Living Kidney Donors: A Longitudinal Study

Amgad E El-Agroudy et al. BJU Int. .
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Objective: To analyse retrospectively the general health status and renal and cardiovascular consequences of living-related kidney donation, as the long-term effects of unilateral nephrectomy for kidney donation are of particular interest with the currently increasing practice of living-donor transplantation.

Patients and methods: Living-related kidney donors (1400) who had donated their kidneys between 1976 and 2002 were asked to attend a dedicated donor follow-up clinic starting in 2004. We attempted to contact all donors to determine the long-term outcome of their remaining kidney. All kidney donors who responded had a detailed assessment, and were questioned about rehabilitation and their feelings on donating a kidney. The data were compared to the age-matched health tables of the Egyptian general population.

Results: In all, 339 donors had a complete evaluation (mean age at the time of evaluation 47.8 years, sd 11; mean follow-up 10.7 years, sd 4.9). The mean (sd) creatinine level after donation was 1.1 (1.2) mg/dL, and creatinine clearance 109 (33) mL/min; the clearance was <60 mL/min in 0.9% of donors and proteinuria was >300 mg/24 h in 1.5% of donors. Seventy-five (22.1%) donors became hypertensive and the rate was higher in donors with an interval of >25 years from donation; 174 (51.3%) of patients became either overweight or obese. Diabetes mellitus developed in 23 (6.8%) and was more common in patients with significant weight gain.

Conclusions: Donor nephrectomy has minimal adverse effects on overall health status. Regular donor follow-up identifies at-risk populations and potentially modifiable factors.

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