An implantable synthetic SPECT lesion: a bridge from phantom to reality

J Nucl Med. 2007 Nov;48(11):1796-9. doi: 10.2967/jnumed.107.046037. Epub 2007 Oct 17.


Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal.

Methods: Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system.

Results: Activity of 7.4-22.2 MBq (0.2-0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk.

Conclusion: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Femur / diagnostic imaging*
  • Mice
  • Phantoms, Imaging*
  • Polyvinyl Chloride
  • Prostheses and Implants
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Tomography, X-Ray Computed


  • Polyvinyl Chloride