B cells in glomerulonephritis: focus on lupus nephritis

Semin Immunopathol. 2007 Nov;29(4):337-53. doi: 10.1007/s00281-007-0092-1. Epub 2007 Oct 18.


The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Antibody Formation*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Dendritic Cells / immunology*
  • Dendritic Cells / pathology
  • Humans
  • Lupus Nephritis / immunology*
  • Lupus Nephritis / pathology
  • Macrophages / immunology*
  • Macrophages / pathology


  • Antibodies