Seroprevalence and genital DNA prevalence of HPV types 6, 11, 16 and 18 in a cohort of young Norwegian women: study design and cohort characteristics

Acta Obstet Gynecol Scand. 2008;87(1):81-8. doi: 10.1080/00016340701714703.


Background: Long-term efficacy evaluations of a quadrivalent HPV type 6/11/16/18 vaccine are ongoing in the Nordic region. As there are limited epidemiological data on HPV infection in Norway, we determined prevalence and identified sociobehavioural correlates of HPV 6/11/16/18 infection in young Norwegian women.

Methods: Norwegian (n=898) women, aged 1624 years, were enrolled in a 4-year prospective study. At enrolment and at 6-month intervals thereafter, an interview on behavioural data and a gynaecological examination were undertaken. Genital samples were tested for the L1,E6 and E7 genes of HPV-6/11/16/18, and serum anti-HPV-6/11/16/18 levels were measured using a competitive Luminex immunoassay (cLIA). Results. DNA and seroprevalence of HPV 6, 11, 16 or 18 ranged from 0.9 to 16.3% and 2.6 to 16.2%,respectively; and most infected women (approximately 75%) were infected with only 1 type. Of the HPV DNA positive cases, 54.3, 50.0,47.3 and 38.5% had detectable HPV 6, 11, 16 or 18 antibodies, respectively. More than 50% of the high-grade cervical intraepithelial neoplasia (CIN) cases were HPV-16 or HPV-18 DNA positive. Lifetime number of partners was the strongest and only predictor of sero- and DNA-positivity across the 4 HPV types.

Conclusion: Given the high prevalence of HPV infection among young women with mostly single-type infection, and the fact that type-specific HPV screening is not recommended prior to the administration of the quadrivalent HPV vaccine, our data suggest the importance of widespread,rather than targeted, immunisation.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alphapapillomavirus / genetics*
  • Alphapapillomavirus / isolation & purification
  • Antibodies, Viral / blood
  • Cohort Studies
  • DNA, Viral / analysis
  • DNA, Viral / genetics
  • Female
  • Humans
  • Norway / epidemiology
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology
  • Polymerase Chain Reaction
  • Prospective Studies
  • Seroepidemiologic Studies
  • Sexual Behavior
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / virology


  • Antibodies, Viral
  • DNA, Viral