[Effect of GABA receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation]

Zh Vyssh Nerv Deiat Im I P Pavlova. Jul-Aug 2007;57(4):479-88.
[Article in Russian]


The influence of systemic injection of GABA-receptor agonist--phenibut (40 mg/kg, s/c) on open field behavior, behavioral reactivity and changes in respiratory parameters after exposure of negative emotional stimuli was studied in three rabbit groups differentiated by locomotor activity in open field (active, passive and medium-active animals). The injection of phenibut results in decrease of rabbits horizontal locomotor activity and some components of research behavior in open field and also decrease of behavioral reactivity on emotional stimuli. At the same time the probability of both an active orienting exploratory or defensive reactions and passive reactions (freezing) were decreased. The influence of phenibut depended on typological features of rabbits: the most potent effect occurred upon behavior of active rabbits, less on passive animals and practically none on medium-active rabbits. The phenibut injection results in increase of duration of inhalation during exposure to emotional stimuli, whereas it decreased in normal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Emotions / drug effects*
  • GABA Agonists / pharmacology*
  • Male
  • Motor Activity / drug effects
  • Rabbits
  • Respiration / drug effects*
  • Stress, Psychological / psychology*
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology


  • GABA Agonists
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid