Combining optical imaging and computational modeling to analyze structure and function of living neurons

Bradley E Losavio; G Duemani Reddy; Costa M Colbert; Ioannis A Kakadiaris; Peter Saggau

doi:10.1109/IEMBS.2006.259552

Combining optical imaging and computational modeling to analyze structure and function of living neurons

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:668-70. doi: 10.1109/IEMBS.2006.259552.

Authors

Bradley E Losavio¹, G Duemani Reddy, Costa M Colbert, Ioannis A Kakadiaris, Peter Saggau

Affiliation

¹ Dept. of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. blosavio@cns.bcm.tmc.edu

PMID: 17946849
DOI: 10.1109/IEMBS.2006.259552

Abstract

We are investigating the computational properties of principal neurons in the mammalian brain. To manage the small size and intricate structure of neuronal dendrites, we employ advanced optical imaging techniques in combination with automatic image reconstruction and computational modeling to study their complex spatio-temporal pattern of activity.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Action Potentials / physiology*
Animals
Brain / physiology*
Brain Mapping / methods*
Cells, Cultured
Computer Simulation
Microscopy, Fluorescence / methods*
Models, Neurological*
Nerve Net / physiology*
Neurons / physiology*
Rats
Systems Integration

Abstract

Publication types

MeSH terms

Grants and funding