Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea

J Gen Virol. 2007 Nov;88(Pt 11):3121-3129. doi: 10.1099/vir.0.83139-0.


Acute-phase sera from >5 % of cases of haemorrhagic fever with renal syndrome occurring annually in Korea have been found to exhibit a fourfold or higher antibody titre to Puumala virus (PUUV) than to Hantaan virus (HTNV) by double-sandwich IgM ELISA, suggesting the existence of a PUUV-related hantavirus. Based on the phylogenetic relationships among arvicolid rodents, the royal vole (Myodes regulus) was targeted as a likely reservoir host of hantavirus. Using RT-PCR, a genetically distinct hantavirus, designated Muju virus (MUJV), was detected in lung tissue of royal voles, captured in widely separated geographical regions in Korea during 1996-2007. Pairwise analysis of the full-length S (1857 nt) and M (3634 nt) segments of MUJV indicated approximately 77 % sequence similarity with PUUV. At the amino acid level, MUJV differed from PUUV by 5.5-6.9 % (nucleocapsid) and 10.0-11.6 % (Gn and Gc envelope glycoproteins). Interstrain variation of MUJV sequences from royal voles captured in different regions suggested geographic-specific clustering. Neutralizing antibody titres against PUUV were two- to sixfold higher than to HTNV in sera of MUJV-infected Myodes regulus. Although virus isolation attempts were unsuccessful, the collective data indicate that MUJV is a distinct hantavirus species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Arvicolinae / virology*
  • Base Sequence
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • DNA, Viral / isolation & purification
  • Hantavirus Infections / veterinary*
  • Korea
  • Lung / virology
  • Molecular Sequence Data
  • Orthohantavirus / classification*
  • Orthohantavirus / isolation & purification*
  • Phylogeny
  • Polymorphism, Genetic
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Viral Proteins / genetics


  • DNA, Complementary
  • DNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/DQ138125
  • GENBANK/DQ138127
  • GENBANK/DQ138128
  • GENBANK/DQ138129
  • GENBANK/DQ138130
  • GENBANK/DQ138131
  • GENBANK/DQ138132
  • GENBANK/DQ138133
  • GENBANK/DQ138134
  • GENBANK/DQ138135
  • GENBANK/DQ138136
  • GENBANK/DQ138137
  • GENBANK/DQ138138
  • GENBANK/DQ138139
  • GENBANK/DQ138140
  • GENBANK/DQ138141
  • GENBANK/DQ138142
  • GENBANK/DQ138143
  • GENBANK/DQ138144
  • GENBANK/EF198313