Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (alpha-aminoacyl)benzotriazoles

Alan R Katritzky; Niveen M Khashab; Megumi Yoshioka; Danniebelle N Haase; Krista R Wilson; Jodie V Johnson; Alfred Chung; Carrie Haskell-Luevano

doi:10.1111/j.1747-0285.2007.00584.x

Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (alpha-aminoacyl)benzotriazoles

Chem Biol Drug Des. 2007 Nov;70(5):465-8. doi: 10.1111/j.1747-0285.2007.00584.x.

Authors

Alan R Katritzky¹, Niveen M Khashab, Megumi Yoshioka, Danniebelle N Haase, Krista R Wilson, Jodie V Johnson, Alfred Chung, Carrie Haskell-Luevano

Affiliation

¹ Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu

PMID: 17949361
DOI: 10.1111/j.1747-0285.2007.00584.x

Abstract

A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(alpha-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.

MeSH terms

Benzene Derivatives / chemical synthesis
Benzene Derivatives / chemistry
Microwaves*
Models, Molecular
Molecular Conformation
Peptides / chemical synthesis*
Peptides / chemistry*
Triazoles / chemical synthesis*
Triazoles / chemistry*

Substances

Benzene Derivatives
Peptides
Triazoles