G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis

FEBS J. 2007 Dec;274(23):6025-36. doi: 10.1111/j.1742-4658.2007.06116.x. Epub 2007 Oct 19.


Akt (also known as protein kinase B) plays an integral role in many intracellular signaling pathways activated by a diverse array of extracellular signals that target several different classes of membrane-bound receptors. Akt plays a particularly prominent part in signaling networks that result in the modulation of cellular proliferation, apoptosis and survival. Thus, the overexpression of Akt subtypes has been measured in a number of cancer types, and dominant-negative forms of Akt can trigger apoptosis and reduce the survival of cancer cells. G protein-coupled receptors act as cell-surface detectors for a diverse spectrum of biological signals and are able to activate or inhibit Akt via several direct and indirect means. In this review, we shall document how G protein-coupled receptors are able to control Akt activity and examine the resulting biochemical and physiological changes, with particular emphasis on cellular proliferation, apoptosis and survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Proliferation*
  • Humans
  • Models, Biological
  • Proto-Oncogene Proteins c-akt / metabolism
  • Proto-Oncogene Proteins c-akt / physiology*
  • Receptors, G-Protein-Coupled / physiology*
  • Signal Transduction


  • Receptors, G-Protein-Coupled
  • Proto-Oncogene Proteins c-akt