Metabolites from the endophytic fungus Phomopsis sp. PSU-D15

Phytochemistry. 2008 Feb;69(3):783-7. doi: 10.1016/j.phytochem.2007.09.006. Epub 2007 Oct 22.

Abstract

From the endophytic fungus Phomopsis sp. PSU-D15, three metabolites named as phomoenamide (1), phomonitroester (2) and deacetylphomoxanthone B (3), were isolated together with three known compounds, dicerandrol A (4), (1S,2S,4S)-p-menthane-1,2,4-triol (5) and uridine. Their structures were elucidated by spectroscopic methods. Phomoenamide (1) exhibited moderate in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Ra.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / metabolism*
  • Antitubercular Agents / pharmacology
  • Ascomycota / chemistry
  • Ascomycota / metabolism*
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Reference Standards
  • Stereoisomerism
  • Uridine / chemistry
  • Uridine / metabolism*
  • Uridine / pharmacology
  • Xanthones / chemistry
  • Xanthones / metabolism*
  • Xanthones / pharmacology

Substances

  • Antitubercular Agents
  • Xanthones
  • dicerandrol A
  • Uridine