A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services

Can J Psychiatry. 2007 Sep;52(9):563-71. doi: 10.1177/070674370705200904.


Objective: The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites.

Method: We evaluated FEP patients (n = 172) treated in specialized programs in 2 medium-sized centres and 1 large urban centre with an identical protocol for demographic variables, diagnosis, and duration of untreated psychosis (DUP) at entry, and positive, negative, and general psychopathology symptoms at entry, 6 months, and 1 year. We used a mixed model analysis of variance, with time and centre and interaction between time and centre as fixed effects and sex and DUP as covariates, to analyze data.

Results: A significant effect of time and time x centre interaction on positive, negative, and general symptom outcome was shown after controlling for ethnicity, education, and diagnosis. Patients showed significantly better outcome on all dimensions of symptoms in the 2 medium-sized centres, compared with the 1 large urban centre. Sex had a significant effect on negative and general symptoms, while DUP had no effect on any outcome measure.

Conclusions: Similarly enriched EI services may produce different outcomes, even within a relatively homogeneous mental health system.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Canada / epidemiology
  • Diagnostic and Statistical Manual of Mental Disorders
  • Early Intervention, Educational / economics
  • Female
  • Humans
  • Incidence
  • Male
  • Mental Health Services / economics
  • Mental Health Services / statistics & numerical data*
  • Middle Aged
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / epidemiology*
  • Psychotic Disorders / therapy*
  • Public Sector*
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome