A backup DNA repair pathway moves to the forefront

Cell. 2007 Oct 19;131(2):223-5. doi: 10.1016/j.cell.2007.10.005.


Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal translocations of lymphoid cancers (Corneo et al., 2007; Soulas-Sprauel et al., 2007; Yan et al., 2007).

MeSH terms

  • DNA Repair / physiology*
  • Humans
  • Lymphoma / genetics*
  • Lymphoma / metabolism
  • Oncogenes / physiology*
  • Receptors, Antigen / physiology*
  • Recombination, Genetic
  • Translocation, Genetic / physiology*


  • Receptors, Antigen