When two is better than one

Cell. 2007 Oct 19;131(2):225-7. doi: 10.1016/j.cell.2007.10.001.


Gene duplication and divergence has long been considered an important route to adaptation and phenotypic evolution. Reporting in Nature, Hittinger and Carroll (2007) provide the first clear example of adaptations in both regulatory regions and protein-coding regions after gene duplication. This combination of evolutionary changes appears to have resolved an adaptive conflict, leading to increased organismal fitness.

MeSH terms

  • Adaptation, Physiological
  • Evolution, Molecular*
  • Gene Duplication*
  • Genetic Variation*
  • Saccharomyces cerevisiae / genetics*