Pathophysiology of tinnitus

Prog Brain Res. 2007;166:19-35. doi: 10.1016/S0079-6123(07)66002-6.


Guided by findings from neural imaging and population responses in humans, where tinnitus is well characterized, several morphological and physiological substrates of tinnitus in animal studies are reviewed. These include changes in ion channels, receptor systems, single unit firing rate, and population responses. Most findings in humans can be interpreted as resulting from increased neural synchrony.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Auditory Pathways / physiopathology*
  • Humans
  • Neurotransmitter Agents / physiology*
  • Tinnitus / etiology
  • Tinnitus / physiopathology*


  • Neurotransmitter Agents