Intracellular magnesium and adipokines in umbilical cord plasma and infant birth size

Pediatr Res. 2007 Dec;62(6):700-3. doi: 10.1203/PDR.0b013e318157d219.


Many epidemiologic studies have disclosed that restricted fetal growth has been associated with an increased risk of insulin resistance in adulthood. We studied the relationship of intracellular magnesium [Mg2+]i in cord blood platelets to adipocytokine and birth size. The subjects were 20 infants with small for gestational age (SGA) and 45 infants with appropriate for gestational age (AGA). By using a fluorescent probe, we examined [Mg2+]i of platelets in the cord blood. Cord plasma insulin, IGF-I, ghrelin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), and leptin levels were determined with the use of ELISA. Mean [Mg2+]i was lower in the SGA than in the AGA groups (p < 0.001). Adiponectin and IGF-I were also lower in the SGA than in the AGA, whereas PAI-1 was higher in the SGA. [Mg2+]i was significantly correlated with birth weight, birth length, and adiponectin. Birth weight was also correlated with cord plasma IGF-I, adiponectin, and leptin. Quantitative insulin sensitivity check index (QUICKI) was lower in the SGA group than in the AGA group. [Mg]i and adiponectin were correlated with QUICKI in all subjects. [Mg]i, as well as leptin and IGF-I, reflect the extent of fetal growth. Decreased [Mg2+]i may be involved in the underlying processes to insulin resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood*
  • Adiponectin / blood
  • Birth Weight*
  • Blood Platelets / chemistry*
  • Body Height*
  • Case-Control Studies
  • Female
  • Fetal Blood / chemistry*
  • Fetal Blood / cytology
  • Gestational Age
  • Ghrelin / blood
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age / blood*
  • Insulin / blood
  • Insulin Resistance
  • Insulin-Like Growth Factor I / analysis
  • Intracellular Fluid / chemistry*
  • Leptin / blood
  • Magnesium / blood*
  • Male
  • Plasminogen Activator Inhibitor 1 / blood


  • ADIPOQ protein, human
  • Adipokines
  • Adiponectin
  • Ghrelin
  • Insulin
  • Leptin
  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human
  • Insulin-Like Growth Factor I
  • Magnesium