Abstract
A 20 years old female patient with epileptic seizures (bilateral myoclonus and generalized tonic-clonic seizures (bilateral myoclonus and generalized tonic-clonic seizures) since the age of 13 was treated with valproic acid. Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred. A causal relationship is suggested.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Drug Therapy, Combination
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Electroencephalography / drug effects
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Epilepsies, Myoclonic / chemically induced*
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Epilepsies, Myoclonic / physiopathology
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Epilepsy, Tonic-Clonic / chemically induced*
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Epilepsy, Tonic-Clonic / physiopathology
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Female
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Humans
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Malaria / physiopathology
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Malaria / prevention & control*
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Mefloquine / administration & dosage
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Mefloquine / adverse effects*
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Phenobarbital / administration & dosage
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Valproic Acid / administration & dosage
Substances
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Valproic Acid
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Mefloquine
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Phenobarbital