Synthesis and biological activity of some novel derivatives of 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole

Molecules. 2007 Jul 27;12(8):1596-605. doi: 10.3390/12081596.


To discover new 1,2,4-triazole derivatives which may possess significant biological activities, we synthesized a series of novel 6-aryl-3-(D-galactopentitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines and 4-(arylmethylidene)amino-5-(D-galactopentitol-1-yl)-3-mercapto-4H-1,2,4-triazoles from 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole. All the title compounds were characterized by elemental analysis, IR, 1H- and 13C-NMR. Plant growth-regulating activity tests showed that these compounds have remarkable effects on the growth of radish and wheat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Raphanus / drug effects*
  • Raphanus / growth & development
  • Sugar Alcohols / pharmacology*
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry
  • Triazoles / pharmacology*
  • Triticum / drug effects*
  • Triticum / growth & development


  • 4-amino-3-(galactopentitol-1-yl)-5-mercapto-1,2,4-triazole
  • Sugar Alcohols
  • Triazoles