The influence of hydrosalpinx on markers of endometrial receptivity

Semin Reprod Med. 2007 Nov;25(6):476-82. doi: 10.1055/s-2007-991045.

Abstract

Hydrosalpinx is a common condition among women of reproductive age. It is related to low pregnancy rates in the settings of in vitro fertilization-embryo transfer programs. Such low rates are not yet well understood, and may be due to poor endometrial receptivity and abnormal expression of key molecules in the endometrium that are important for implantation. The available data on the inflammatory response, endometrial blood flow, integrins, leukemia inhibitory factor, matrix metalloproteinases, and homeobox gene A10 expression in the presence of hydrosalpinx are reviewed. In addition, the evidence for treatment options to improve pregnancy rates is also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Embryo Implantation*
  • Endometrium / blood supply
  • Endometrium / enzymology
  • Endometrium / metabolism*
  • Endometrium / physiopathology
  • Fallopian Tube Diseases / enzymology
  • Fallopian Tube Diseases / metabolism*
  • Fallopian Tube Diseases / physiopathology
  • Fallopian Tube Diseases / therapy
  • Female
  • Fertilization in Vitro
  • Homeobox A10 Proteins
  • Homeodomain Proteins / metabolism
  • Humans
  • Inflammation Mediators / metabolism
  • Integrins / metabolism
  • Leukemia Inhibitory Factor / metabolism
  • Matrix Metalloproteinases / metabolism
  • Pregnancy
  • Regional Blood Flow
  • Treatment Outcome

Substances

  • Biomarkers
  • Homeobox A10 Proteins
  • Homeodomain Proteins
  • Inflammation Mediators
  • Integrins
  • Leukemia Inhibitory Factor
  • Hoxa10 protein, mouse
  • Matrix Metalloproteinases