HIV-1 drug-resistance and drug-dependence

Retrovirology. 2007 Oct 25;4:78. doi: 10.1186/1742-4690-4-78.

Abstract

In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1 variants is also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-HIV Agents / adverse effects*
  • Drug Resistance
  • Enfuvirtide
  • Genetic Variation
  • HIV Envelope Protein gp41 / therapeutic use
  • HIV Fusion Inhibitors / therapeutic use
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • Peptide Fragments / therapeutic use
  • Phenotype
  • Viral Envelope Proteins / genetics

Substances

  • Anti-HIV Agents
  • HIV Envelope Protein gp41
  • HIV Fusion Inhibitors
  • Peptide Fragments
  • Viral Envelope Proteins
  • Enfuvirtide