Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

Biochim Biophys Acta. 2008 Mar;1778(3):794-809. doi: 10.1016/j.bbamem.2007.09.003. Epub 2007 Sep 15.

Abstract

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions. These junctional complexes are related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization. Endothelial junctional proteins play important roles in tissue integrity but also in vascular permeability, leukocyte extravasation and angiogenesis. In this review, we will focus on specific mechanisms of endothelial tight and adherens junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adherens Junctions / physiology*
  • Adherens Junctions / ultrastructure*
  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / physiology
  • Cadherins / chemistry
  • Cadherins / physiology
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / physiology
  • Cell Proliferation
  • Contact Inhibition
  • Endothelial Cells / physiology*
  • Endothelial Cells / ultrastructure*
  • Homeostasis
  • Humans
  • Inflammation / pathology
  • Inflammation / physiopathology
  • Membrane Proteins / chemistry
  • Membrane Proteins / physiology
  • Models, Biological
  • Models, Molecular
  • Multiprotein Complexes
  • Neovascularization, Physiologic
  • Signal Transduction
  • Tight Junctions / physiology*
  • Tight Junctions / ultrastructure*
  • beta Catenin / chemistry
  • beta Catenin / physiology

Substances

  • Antigens, CD
  • Cadherins
  • Cell Adhesion Molecules
  • Membrane Proteins
  • Multiprotein Complexes
  • beta Catenin
  • cadherin 5