Isolation, identification and synthesis of locustamyoinhibiting peptide (LOM-MIP), a novel biologically active neuropeptide from Locusta migratoria

Regul Pept. 1991 Oct 1;36(1):111-9. doi: 10.1016/0167-0115(91)90199-q.


A novel peptide termed locustamyoinhibiting peptide (LOM-MIP) was isolated from brain-corpora cardiaca-corpora allata-suboesophageal ganglion extracts of the locust, Locusta migratoria. The primary structure of this nonapeptide has been determined Ala-Trp-Gln-Asp-Leu-Asn-Ala-Gly-Trp-NH2. LOM-MIP suppresses the spontaneous contractions of the hindgut and oviduct of Locusta migratoria and of the hindgut of Leucophaea maderae. This novel peptide is, however, structurally different from leucomyosuppressin, a hindgut suppressing peptide isolated from Leucophaea maderae heads. LOM-MIP has a Gly-TrpNH2 carboxy-terminal in common with APGWamide, a penis retractor muscle inhibiting peptide isolated from the snail, Lymnea stagnalis. In addition, it shows carboxy-terminal sequence similarities with locust AKH II which ends in AGWamide. No sequence similarities were found with other vertebrate or invertebrate peptides. Synthetic LOM-MIP showed biological as well as chemical characteristics indistinguishable from those of native LOM-MIP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Corpora Allata / chemistry
  • Digestive System / drug effects
  • Digestive System Physiological Phenomena
  • Grasshoppers / physiology*
  • Insect Hormones / chemistry*
  • Insect Hormones / isolation & purification
  • Insect Hormones / pharmacology
  • Insect Proteins*
  • Molecular Sequence Data
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology*
  • Nerve Tissue / chemistry*
  • Neuropeptides / chemistry*
  • Neuropeptides / isolation & purification
  • Neuropeptides / pharmacology
  • Neurosecretory Systems / chemistry
  • Oviducts / drug effects
  • Oviducts / physiology
  • Sequence Homology, Nucleic Acid


  • Insect Hormones
  • Insect Proteins
  • Neuropeptides
  • locustamyoinhibiting peptide, Locusta migratoria