Analysis of the peripheral T-cell compartment in the MHC class II deficiency syndrome

Res Immunol. 1991 Nov-Dec;142(9):789-98. doi: 10.1016/0923-2494(91)90124-2.


To analyse the impact of lack of MHC class II expression on the composition of the peripheral T-cell compartment in man, the expression characteristics of several membrane antigens were examined on peripheral blood lymphocytes (PBL) and cultured T cells derived from an MHC-class-II-deficient patient. No MHC class II expression could be detected on either PBL or activated T cells. Moreover, the expression of MHC class I was reduced both on PBL and in vitro activated T cells compared to the healthy control. However, the reduced expression of CD26 observed on the PBL of the patient was restored after in vitro expansion. Despite the presumably class-II-deficient thymic environment, a distinct but reduced single CD4+ T-cell population was observed in the PBL of the patient. After in vitro expansion, the percentage of CD4+ cells dropped even further, most likely due to a proliferative disadvantage, compared to the single CD8+ T-cell population. However, proliferation analysis showed that T-cell activation via the TcR/CD3 pathway is not affected by the MHC class II deficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / immunology*
  • Blotting, Northern
  • Cell Line
  • Flow Cytometry
  • Genes, MHC Class II*
  • Humans
  • Immunologic Deficiency Syndromes / immunology*
  • Lymphocyte Activation / immunology*
  • T-Lymphocytes / immunology*


  • Antigens, CD