Synthesis and antifungal bioactivities of 3-alkylquinazolin- 4-one derivatives

Molecules. 2006 Jun 12;11(6):383-92. doi: 10.3390/11060383.


A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology*
  • Fusarium / drug effects
  • Gibberella / drug effects
  • Quinazolinones / chemical synthesis*
  • Quinazolinones / pharmacology*


  • Antifungal Agents
  • Quinazolinones