Non-sequential fractional ultrapulsed CO2 resurfacing of photoaged facial skin: preliminary clinical report

J Cosmet Laser Ther. 2007 Dec;9(4):218-25. doi: 10.1080/14764170701632901.


This study evaluates results, adverse side effects and downtime of the protocol 'ActiveFX' for photodamaged facial skin. A non-sequential fractional ultrapulsed CO2 laser with specific settings is used in addition to a new computer pattern generator (CPG). From September 2006 to March 2007, 55 patients underwent this new 'soft' single-session, single-pass and full-face ablative fractional treatment. The patients were evaluated at baseline and 1 and 3 months after the treatment using a five-point scale. Seven aspects of photodamaged skin were recorded: global score, fine lines, mottled pigmentation, sallow complexion, tactile roughness, coarse wrinkles and telangiectasias. The results were compared with a non-parametric statistical test, the Wilcoxon's exact test. Eight patients received a double-pass treatment on the crow's feet regions and the improvement of the coarse wrinkles was analyzed with a quartile grading scale. Significant differences (p<0.05) between baseline and 1 and 3 months post-treatment were observed for all features except telangiectasias. Coarse wrinkles presented a good improvement only in the regions submitted to a double-pass. Minimal and isolated adverse side effects were noted and the downtime was very low. Non-sequential fractional ultrapulsed CO2 light treatment ('ActiveFX') can be considered an excellent alternative for photodamaged facial skin.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Carbon Dioxide / administration & dosage*
  • Carbon Dioxide / adverse effects
  • Dermatologic Surgical Procedures
  • Dose Fractionation, Radiation
  • Female
  • Follow-Up Studies
  • Humans
  • Lasers, Solid-State / adverse effects*
  • Lasers, Solid-State / therapeutic use*
  • Male
  • Middle Aged
  • Pigmentation Disorders / diagnosis
  • Pigmentation Disorders / therapy*
  • Rejuvenation
  • Skin Aging / pathology
  • Skin Aging / radiation effects*
  • Treatment Outcome


  • Carbon Dioxide