Crossover interference underlies sex differences in recombination rates

Trends Genet. 2007 Nov;23(11):539-42. doi: 10.1016/j.tig.2007.08.015. Epub 2007 Oct 26.


In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.

MeSH terms

  • Animals
  • Crossing Over, Genetic*
  • Female
  • Male
  • Meiosis
  • Mice
  • Pachytene Stage
  • Recombination, Genetic
  • Sex Characteristics
  • Sex Chromosomes