Cranial nerve palsies accompanying pituitary tumour

J Clin Neurosci. 2007 Dec;14(12):1158-62. doi: 10.1016/j.jocn.2006.07.016. Epub 2007 Oct 26.


We reviewed 12 patients with pituitary tumour and cranial nerve palsy to analyse the clinical characteristics, the radiographic appearances, and the outcome after surgery. All patients had pathologically nonfunctioning macroadenomas with evidence of apoplexy. The third cranial nerve was the most frequently affected, followed by the sixth and fourth cranial nerves. Third cranial nerve palsy manifested as a symptom sequence comprising mydriasis, followed by limitation of gaze and ptosis. These symptoms recovered in reverse order of development. The time taken for recovery of cranial nerve palsy after surgery was significantly correlated with the length of time between the onset of symptoms and surgery. Pituitary apoplexy appears to be the primary cause of cranial nerve palsy with pituitary tumour. Early surgical intervention is most likely to bring about rapid recovery from cranial nerve dysfunction.

MeSH terms

  • Abducens Nerve Diseases / etiology
  • Adult
  • Aged
  • Cerebral Angiography
  • Cranial Nerve Diseases / etiology*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Oculomotor Nerve Diseases / etiology
  • Pituitary Neoplasms / complications*
  • Pituitary Neoplasms / surgery
  • Retrospective Studies
  • Treatment Outcome
  • Trochlear Nerve Diseases / etiology