Clinical strategies to enhance T cell reconstitution

Semin Immunol. 2007 Oct;19(5):289-96. doi: 10.1016/j.smim.2007.08.001. Epub 2007 Oct 26.


Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fibroblast Growth Factor 7 / pharmacology
  • Gonadal Steroid Hormones / physiology
  • Growth Hormone / pharmacology
  • Hematopoietic Stem Cells / physiology
  • Humans
  • Interleukin-7 / pharmacology
  • T-Lymphocytes / physiology*


  • Gonadal Steroid Hormones
  • Interleukin-7
  • Fibroblast Growth Factor 7
  • Growth Hormone