[Tumor angiogenesis]

Bull Cancer. 2007;94(7 Suppl):F193-8.
[Article in French]

Abstract

Following the work of Folkman, it appears that angiogenesis, which consists in the formation of new blood vessels able to deliver oxygen and nutriments to tumor cells, is a major step in the evolution of tumors, which can only grow after the onset of the angiogenic switch. Numerous factors play a role in angiogenesis stimulation or inhibition : the vascular endothelial growth factor and fibroblastic growth factors as well as angiopoietin are proangiogenic, whereas angiostatin and platelet factor 4 are anti-angiogenic. The discovery of these molecules and of the molecular mechanisms of their activity allowed the identification of new therapeutic targets, which appear relevant for the treatment of cancer.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Angiopoietins / physiology
  • Fibroblast Growth Factors / physiology*
  • Humans
  • Lymphangiogenesis / physiology*
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic / etiology*
  • Vascular Endothelial Growth Factor A / physiology
  • Vascular Endothelial Growth Factors / physiology*

Substances

  • Angiopoietins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Fibroblast Growth Factors