Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors

Adv Exp Med Biol. 2007;603:88-96. doi: 10.1007/978-0-387-72124-8_7.

Abstract

Disruption of lipopolysaccharide (LPS) biosynthesis genes in an epidemiologically significant Yersinia pestis strain showed that the ability to synthesize the full inner core of the LPS is crucial for resistances to the bactericidal action of antimicrobial peptides and to complement-mediated serum killing. Resistance to polymyxin B also requires a high content of the cationic sugar, 4-amino-4-deoxy-L-arabinose, in lipid A.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antimicrobial Cationic Peptides / pharmacology
  • Blood Bactericidal Activity
  • Carbohydrate Sequence
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial
  • Humans
  • In Vitro Techniques
  • Lipopolysaccharides / chemistry*
  • Molecular Sequence Data
  • Molecular Structure
  • Mutation
  • Polymyxin B / pharmacology
  • Spectrometry, Mass, Electrospray Ionization
  • Yersinia pestis / chemistry*
  • Yersinia pestis / drug effects
  • Yersinia pestis / genetics

Substances

  • Antimicrobial Cationic Peptides
  • Lipopolysaccharides
  • Polymyxin B