Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (6), 641-9

Sleep-disordered Breathing With Chronic Opioid Use

Affiliations
Review

Sleep-disordered Breathing With Chronic Opioid Use

Harry Teichtahl et al. Expert Opin Drug Saf.

Abstract

Chronic opioid use for pain relief or as substitution therapy for illicit drug abuse is prevalent in our societies. In the US, retail distribution of methadone and oxycodone has increased by 824 and 660%, respectively, between 1997 and 2003. Mu-opioids depress respiration and deaths related to illicit and non illicit chronic opioid use are not uncommon. Since 2001 there has been an emerging literature that suggests that chronic opioid use is related to central sleep apnoea of both periodic and non-periodic breathing types, and occurs in approximately 30% of these subjects. The clinical significance of these sleep-related abnormalities are unknown. This review addresses the present knowledge of control of ventilation mechanisms during wakefulness and sleep, the effects of opioids on ventilatory control mechanisms, the sleep-disordered breathing found with chronic opioid use and a discussion regarding the future research directions in this area.

Similar articles

  • Sleep Among Opioid Users
    AK Paturi et al. Postgrad Med 123 (3), 80-7. PMID 21566418.
    Use of opioids in the treatment of both acute and chronic pain has increased significantly in the past 2 decades. Recent literature suggests that chronic opioid use is re …
  • Opioids, Sleep Architecture and Sleep-Disordered Breathing
    D Wang et al. Sleep Med Rev 11 (1), 35-46. PMID 17141540. - Review
    Opioid use whether acute or chronic, illicit or therapeutic is prevalent in Western societies. Opioid receptors are located in the same nuclei that are active in sleep re …
  • [Opioids and Sleep Disordered Breathing]
    R Heinzer. Rev Med Suisse 5 (226), 2322-4, 2326-8. PMID 20052864. - Review
    Medical use of chronic opioids has recently increased in Switzerland. Even though their effect on daytime vigilance tends to disappear after some time, 70% of chronic opi …
  • Are Opioids Associated With Sleep Apnea? A Review of the Evidence
    JM Walker et al. Curr Pain Headache Rep 13 (2), 120-6. PMID 19272277. - Review
    Chronic opioid use for nonmalignant pain has increased dramatically; nonillicit unintentional deaths have also increased. This article reviews the physiology of breathing …
  • Opioid Medication and Sleep-Disordered Breathing
    HJ Yue et al. Med Clin North Am 94 (3), 435-46. PMID 20451025. - Review
    There has been a growing recognition of chronic pain that may be experienced by patients. There has been a movement toward treating these patients aggressively with pharm …
See all similar articles

Cited by 11 PubMed Central articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback