A low-carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and non-diabetic subjects

Diabet Med. 2007 Dec;24(12):1430-5. doi: 10.1111/j.1464-5491.2007.02290.x. Epub 2007 Oct 29.

Abstract

Background: Low-carbohydrate diets are effective for weight reduction in people without diabetes, but there is limited evidence for people with Type 2 diabetes. Aims To assess the impact of a low-carbohydrate diet on body weight, glycated haemoglobin (HbA(1c)), ketone and lipid levels in diabetic and non-diabetic subjects.

Methods: Thirteen Type 2 diabetic subjects (on diet or metformin) and 13 non-diabetic subjects were randomly allocated to either a low-carbohydrate diet (< or = 40 g carbohydrate/day) or a healthy-eating diet following Diabetes UK nutritional recommendations and were seen monthly for 3 months. Subjects (25% male) were (mean +/- sd) age 52 +/- 9 years, weight 96.3 +/- 16.6 kg, body mass index 35.1 kg/m(2), HbA(1c) 6.6 +/- 1.1%, total cholesterol 5.1 +/- 1.1 mmol/l, high-density lipoprotein cholesterol 1.3 +/- 0.4 mmol/l, low-density lipoprotein cholesterol 3.1 +/- 0.9 mmol/l, triglycerides (geometric mean) 1.55 (1.10, 2.35) mmol/l and ketones range 0.0-0.2 mmol/l.

Results: Analysis was by intention to treat with last observation carried forward. Twenty-two of the participants (85%) completed the study. Weight loss was greater (6.9 vs. 2.1 kg, P = 0.003) in the low-carbohydrate group, with no difference in changes in HbA(1c), ketone or lipid levels.

Conclusions: The diet was equally effective in those with and without diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Body Weight
  • Cholesterol / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diet, Carbohydrate-Restricted*
  • Dietary Carbohydrates* / administration & dosage
  • Feeding Behavior*
  • Female
  • Glycated Hemoglobin A
  • Humans
  • Ketones / blood
  • Male
  • Middle Aged
  • Obesity / blood
  • Obesity / complications
  • Obesity / diet therapy*
  • Triglycerides / blood

Substances

  • Dietary Carbohydrates
  • Glycated Hemoglobin A
  • Ketones
  • Triglycerides
  • Cholesterol