The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1

Biochem Biophys Res Commun. 2007 Dec 28;364(4):959-65. doi: 10.1016/j.bbrc.2007.10.102. Epub 2007 Oct 29.


The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Cell Adhesion Molecules / metabolism*
  • Cell Line
  • Humans
  • Kidney / metabolism*
  • Membrane Glycoproteins
  • Membrane Proteins / metabolism*
  • Mice
  • Nectins
  • Platelet Glycoprotein GPIb-IX Complex
  • Rats
  • Receptors, Virus / metabolism*
  • T-Lymphocytes / metabolism*


  • Antigens, CD
  • CD96 antigen
  • Cell Adhesion Molecules
  • Membrane Glycoproteins
  • Membrane Proteins
  • NECTIN1 protein, human
  • Nectin1 protein, mouse
  • Nectins
  • Platelet Glycoprotein GPIb-IX Complex
  • Receptors, Virus
  • adhesion receptor
  • poliovirus receptor