Comparison of the Effectiveness of Geranylgeranylacetone With Cimetidine in Gastritis Patients With Dyspeptic Symptoms and Gastric Lesions: A Randomized, Double-Blind Trial in Japan

Digestion. 2007;75(4):215-24. doi: 10.1159/000110654. Epub 2007 Oct 30.


Background and aim: Controversy remains regarding the treatment of choice for chronic gastritis patients with dyspeptic symptoms when Helicobacter pylori eradication is not indicated or fails for their gastric lesions. A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H(2)-receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms.

Methods: 128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared.

Results: Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups.

Conclusion: GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Ulcer Agents / therapeutic use*
  • Cimetidine / therapeutic use*
  • Diterpenes / therapeutic use*
  • Double-Blind Method
  • Dyspepsia / drug therapy*
  • Dyspepsia / microbiology
  • Female
  • Gastritis / drug therapy*
  • Gastritis / microbiology
  • Gastroscopy
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Statistics, Nonparametric
  • Treatment Outcome


  • Anti-Ulcer Agents
  • Diterpenes
  • Cimetidine
  • geranylgeranylacetone