NKT cells: In the beginning.

Eur J Immunol. 2007 Nov:37 Suppl 1:S111-5. doi: 10.1002/eji.200737527.

Abstract

Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.

Publication types

  • Historical Article

MeSH terms

  • Allergy and Immunology / history*
  • Animals
  • Cytotoxicity, Immunologic*
  • History, 20th Century
  • Humans
  • Killer Cells, Natural / immunology*
  • Receptors, Antigen, T-Cell / genetics
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Receptors, Antigen, T-Cell