Vitamin A: is it a risk factor for osteoporosis and bone fracture?

Nutr Rev. 2007 Oct;65(10):425-38. doi: 10.1111/j.1753-4887.2007.tb00268.x.


Results from observational studies of the association between vitamin A intake or serum concentration and bone mineral density or fracture are mixed. The inconsistencies may be due, in part, to difficulties in obtaining an accurate assessment of vitamin A intake or status. Serum retinol is a poor measure of vitamin A status because it is subject to homeostatic control. Stable-isotope-dilution methodology gives a validated assessment of the total-body and liver vitamin A stores and is recommended in future studies on vitamin A status and osteoporosis. The potential for exacerbating an already serious public health problem with intakes of vitamin A currently considered safe indicates further research into this matter is warranted.

Publication types

  • Review

MeSH terms

  • Bone Density / drug effects*
  • Fractures, Bone / etiology
  • Humans
  • Osteoporosis / blood
  • Osteoporosis / chemically induced*
  • Risk Factors
  • Vitamin A* / administration & dosage
  • Vitamin A* / adverse effects
  • Vitamin A* / blood
  • Vitamins / administration & dosage
  • Vitamins / adverse effects
  • Vitamins / blood


  • Vitamins
  • Vitamin A