[Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients]

Zhongguo Zhong Yao Za Zhi. 2007 Aug;32(15):1566-8.
[Article in Chinese]


Objective: To investigate the effect of dongchong xiacao capsule on the airway inflammation of asthmatic patients and to explore the relevant mechanism of therapeutic effect of Dongchongxiacao capsule.

Method: Sixty patients with moderate persistent asthma were randomized into the treatment group (n=30) and the control group (n=30). Inhaled corticosteroid and as-needed beta-agonist were used in the treatment group while this therapy plus dongchong xiacao capsule were used in the control group for two months. Serum IL-4, IFN-gamma, sICAM-1, MMP-9, IgG, IgE level were assessed at randomization and 2 months after randomization.

Result: The serum level of IgE, sICAM-1, IL-4 and MMP-9 of the treatment group was lowered to a greater degree than that of the control group (P < 0.05 or P < 0.01 ).

Conclusion: Dongchong xiacao capsule can reduce the serum markers of airway inflammation, which suggests this therapy bares the anti-inflammation effects probably through regulating the balance of TH1/TH2, inhibiting the activity of adherence molecule and reducing IgE production. It may also have the effect of reversing airway remodeling, which needs further research to determine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Asthma / drug therapy*
  • Asthma / immunology
  • Bronchitis / drug therapy*
  • Bronchitis / immunology
  • Capsules
  • Cordyceps* / chemistry
  • Female
  • Humans
  • Immunoglobulin E / blood
  • Intercellular Adhesion Molecule-1 / blood
  • Interferon-gamma / blood
  • Interleukin-4 / blood
  • Male
  • Materia Medica / isolation & purification
  • Materia Medica / pharmacology*
  • Middle Aged
  • Th1 Cells / immunology
  • Th2 Cells / immunology


  • Capsules
  • Materia Medica
  • Intercellular Adhesion Molecule-1
  • Interleukin-4
  • Immunoglobulin E
  • Interferon-gamma