Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study

Am J Ind Med. 2007 Dec;50(12):969-79. doi: 10.1002/ajim.20523.


Background: Farmers have increased risk for chronic bronchitis. Few investigators have considered pesticides.

Methods: We evaluated pesticides as risk factors for chronic bronchitis using the Agricultural Health Study enrollment data on lifetime pesticide use and history of doctor-diagnosed chronic bronchitis from 20,908 private pesticide applicators, primarily farmers.

Results: A total of 654 farmers (3%) reported chronic bronchitis diagnosed after age 19. After adjustment for correlated pesticides as well as confounders, 11 pesticides were significantly associated with chronic bronchitis. Heptachlor use had the highest odds ratio (OR=1.50, 95% Confidence Interval (CI)=1.19, 1.89). Increased prevalence for chronic bronchitis was also seen for individuals who had a history of a high pesticide exposure event (OR=1.85, 95% CI=1.51, 2.25) and for those who also applied pesticides in off-farm jobs (OR=1.40, 95% CI=1.04, 1.88). Co-morbid asthma and current farm activities did not explain these results.

Conclusions: These results provide preliminary evidence that pesticide use may increase chronic bronchitis prevalence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Agriculture*
  • Bronchitis / diagnosis
  • Bronchitis / epidemiology*
  • Bronchitis / etiology
  • Chronic Disease
  • Female
  • Heptachlor / toxicity
  • Humans
  • Male
  • Middle Aged
  • North Carolina / epidemiology
  • Occupational Diseases / diagnosis
  • Occupational Diseases / epidemiology*
  • Occupational Diseases / etiology
  • Occupational Exposure / adverse effects*
  • Occupational Health*
  • Pesticides / toxicity*
  • Prospective Studies
  • Respiratory Tract Diseases / epidemiology
  • Risk Factors


  • Pesticides
  • Heptachlor