Abstract
A simple and highly effective C-O(carboxylic) coupling reaction catalyzed by copper(I) salts has been developed to synthesize benzopyranones. The reaction of various 2-halobiarylcarboxylic acids was examined using microwave irradiation. A new class of pyrroloisoquinoline alkaloid, isolamellarin, was synthesized based on the annulation of dihydroisoquinoline with aryl pyruvates under basic condition and Cu-mediated/MW-assisted C-O(carboxylic) lactonization.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Alkaloids / chemical synthesis*
-
Antineoplastic Agents / chemical synthesis*
-
Carboxylic Acids / chemistry*
-
Catalysis
-
Copper / chemistry*
-
Coumarins / chemical synthesis*
-
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
-
Hydrocarbons, Cyclic / chemistry*
-
Microwaves*
-
Models, Chemical
Substances
-
Alkaloids
-
Antineoplastic Agents
-
Carboxylic Acids
-
Coumarins
-
Heterocyclic Compounds, 4 or More Rings
-
Hydrocarbons, Cyclic
-
lamellarin alpha
-
Copper