A modern approach to tuberculous pericarditis

Prog Cardiovasc Dis. Nov-Dec 2007;50(3):218-36. doi: 10.1016/j.pcad.2007.03.002.

Abstract

The human immunodeficiency virus (HIV) epidemic has been associated with an increase in all forms of extrapulmonary tuberculosis including tuberculous pericarditis. Tuberculosis is responsible for approximately 70% of cases of large pericardial effusion and most cases of constrictive pericarditis in developing countries, where most of the world's population live. However, in industrialized countries, tuberculosis accounts for only 4% of cases of pericardial effusion and an even smaller proportion of instances of constrictive pericarditis. Tuberculous pericarditis is a dangerous disease with a mortality of 17% to 40%; constriction occurs in a similar proportion of cases after tuberculous pericardial effusion. Early diagnosis and institution of appropriate therapy are critical to prevent mortality. A definite or proven diagnosis is based on demonstration of tubercle bacilli in pericardial fluid or on histologic section of the pericardium. A probable or presumed diagnosis is based on proof of tuberculosis elsewhere in a patient with otherwise unexplained pericarditis, a lymphocytic pericardial exudate with elevated biomarkers of tuberculous infection, and/or appropriate response to a trial of antituberculosis chemotherapy. Treatment consists of 4-drug therapy (isoniazid, rifampicin, pyrazinamide, and ethambutol) for 2 months followed by 2 drugs (isoniazid and rifampicin) for 4 months regardless of HIV status. It is uncertain whether adjunctive corticosteroids are effective in reducing mortality or pericardial constriction, and their safety in HIV-infected patients has not been established conclusively. Surgical resection of the pericardium is indicated for those with calcific constrictive pericarditis or with persistent signs of constriction after a 6 to 8 week trial of antituberculosis treatment in patients with noncalcific constrictive pericarditis.

Publication types

  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections* / complications
  • AIDS-Related Opportunistic Infections* / diagnosis
  • AIDS-Related Opportunistic Infections* / drug therapy
  • AIDS-Related Opportunistic Infections* / epidemiology
  • AIDS-Related Opportunistic Infections* / microbiology
  • AIDS-Related Opportunistic Infections* / surgery
  • Adrenal Cortex Hormones / therapeutic use
  • Antitubercular Agents / therapeutic use
  • Echocardiography
  • Electrocardiography
  • Humans
  • Mycobacterium tuberculosis*
  • Pericardial Effusion / drug therapy
  • Pericardial Effusion / microbiology*
  • Pericardial Effusion / pathology
  • Pericardial Effusion / surgery
  • Pericardiectomy
  • Pericardiocentesis
  • Pericarditis, Constrictive / drug therapy
  • Pericarditis, Constrictive / microbiology*
  • Pericarditis, Constrictive / pathology
  • Pericarditis, Constrictive / surgery
  • Pericarditis, Tuberculous / complications
  • Pericarditis, Tuberculous / diagnosis*
  • Pericarditis, Tuberculous / drug therapy
  • Pericarditis, Tuberculous / epidemiology
  • Pericarditis, Tuberculous / microbiology
  • Pericarditis, Tuberculous / surgery
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Antitubercular Agents