Activation of the calpain/cdk5/p25 Pathway in the Girus Cinguli in Parkinson's Disease

Parkinsonism Relat Disord. 2008;14(4):309-13. doi: 10.1016/j.parkreldis.2007.09.005. Epub 2007 Oct 31.

Abstract

The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Calpain / metabolism*
  • Case-Control Studies
  • Cyclin-Dependent Kinase 5 / metabolism*
  • Female
  • Gyrus Cinguli / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / metabolism*
  • Parkinson Disease / metabolism
  • Parkinson Disease / pathology*
  • Signal Transduction / physiology*

Substances

  • Nerve Tissue Proteins
  • p25 protein, human
  • Cyclin-Dependent Kinase 5
  • Calpain