Reduced anti-PRP antibody response to Hib immunisation in preterm (<32 weeks) UK infants who received inactivated polio (eIPV)

Vaccine. 2007 Nov 28;25(49):8206-8. doi: 10.1016/j.vaccine.2007.09.060. Epub 2007 Oct 16.

Abstract

A vaccine containing inactivated polio (eIPV) (Pediacel) is now used in the UK. The effect of the eIPV on other components is not well understood. We studied Haemophilus influenzae type b (Hib) and tetanus responses in preterm infants, <32 weeks gestation at birth, immunised with the (then) standard UK primary vaccines and either oral polio vaccine (OPV) or eIPV and analysed the effect showing reduced Hib responses with eIPV.

Publication types

  • Clinical Trial

MeSH terms

  • Antibodies, Bacterial / blood*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
  • Haemophilus Infections / prevention & control
  • Haemophilus Vaccines / administration & dosage*
  • Haemophilus Vaccines / immunology
  • Haemophilus influenzae type b / immunology*
  • Humans
  • Immunization
  • Infant
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight
  • Poliovirus Vaccine, Inactivated / administration & dosage*
  • Poliovirus Vaccine, Oral / administration & dosage
  • Polysaccharides / immunology*
  • Tetanus Toxoid / immunology
  • United Kingdom
  • Vaccines, Combined

Substances

  • Antibodies, Bacterial
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccine, Oral
  • Polysaccharides
  • Tetanus Toxoid
  • Vaccines, Combined
  • polyribitol phosphate